When screening for a
multitude of microorganisms in the laboratory, the ones which promise
results for an industrial process are separated from the ones which do
not meet expectations. Now comes the most difficult part of the whole
process, where the exact optimum growth conditions of the microorganism
needs to be mimicked in the laboratory.
microorganism requires a host of nutrients in its growth media to
multiply quickly and produce the desired products, but designing an
optimum growth media is no simple task. Our Scientists work hard to
understand the metabolism process of the microorganism and its
behaviour in various media sources. A media composition which works
well for one strain may not work well for another. The growth may be
limited hence the limited production of the required products. This
hampers the economic feasibility of the production source.
key is finding an optimum nutrient medium which allows the
microorganism to achieve the highest growth and produce the product of
interest in high volumes. Our team of Scientists and Biochemists
work to identify this and develop a solution which
guarantees the most valid results.
an optimum growth medium is not the only part of turning the
microorganism of interest into a powerful producer. A strain isolated
from soil conditions is commonly refered to as Wild type, since it
produces a host of other products along with the product of interest.
This poses two problems: The yield of the product of interest
relatively low due to production of by-products and the growth medium
contains by-products which are not of economic important or sometimes
may even be restricted for the targeted end use.
another objective of an efficient process development is preparing a
microorganism which does not produce unwanted by-products while
enhancing the production capability of the product of interest. This is
referred to as Strain improvement and is achieved by Induced Mutations
or by Recombinant Technology. Both these processes alter the genetic
structure of the microorganism bringing changes to its behaviour. If
properly directed, these processes bring efficient changes to the gene
of the microorganism such as changed or lower medium nutritional
requirements and increased productivity of the product of interest.
conducting Induced Mutations, a wide variety of mutants are developed
hence the organisms are screened further to select the mutated strains
of interest. Induced Mutations are carried out by select Chemical
Mutagens, UV-radiation or sometimes both.
at Noor Creations are looking to constantly innovate in Strain
improvement of our existing and newly isolated microorganisms to become
more efficient by the day.